Pediatric reference intervals should reflect not only age and sex, but also the ongoing growth and development of children. Although reference intervals established for a specific population using a specific platform can be transferred to other laboratories after appropriate verification, intervals for adults cannot be reliably adopted for the interpretation of test results of pediatric patients. The Clinical and Laboratory Standards Institute (CLSI) EP28-A3c guidelines describe procedures for establishing reference intervals in a clinical laboratory. Reliable reference intervals for laboratory tests are critical guides for clinicians to diagnose diseases or make medical decisions. ![]() Keywords: Reference intervals, Indirect sampling, Korean pediatrics, Age-partitioned groups, Sex-partitioned groups, Multicenter These reference intervals would be valuable for clinical evaluations in the Korean pediatric population. Erythrocyte sedimentation rate, monocyte percentage, basophil percentage, activated partial thromboplastin time, glucose, cholesterol, albumin, bilirubin, chloride, and C-reactive protein did not show any difference between age- or sex-partitioned subgroups.Ĭonclusions: We determined Korean pediatric reference intervals for hematology, coagulation, and chemistry tests by indirect sampling based on medical record data from multiple institutions. Most tests required age-specific partitioning, and some of those required sex-specific partitioning for at least one age-partitioned subgroup. Results: The pediatric reference intervals determined in this study were different from existing adult reference intervals and pediatric reference intervals for other ethnicities. Age- and sex-specific reference intervals for routine laboratory tests were defined based on the Clinical and Laboratory Standards Institute (CLSI) EP28-A3c guidelines. Methods: Preoperative laboratory test results from 1,031 pediatric patients aged 0 month–18 years who underwent minor surgeries in four university hospitals were collected. We aimed to establish reference intervals for routine laboratory tests for Korean pediatric patients through retrospective multicenter data analysis. ![]() ![]() Pediatric reference intervals are difficult to establish because children are in their growing stage and their physiology changes continuously. 1ġDepartment of Laboratory Medicine, Seoul National University Hospital and College of Medicine, Seoul, Korea 2Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea 3Department of Laboratory Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea 4Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea 5Department of Biostatistics, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Koreaĭepartment of Laboratory Medicine, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, KoreaĮ-mail: These authors equally contributed to this study.īackground: Reference intervals defined for adults or children of other ethnicities cannot be applied in the evaluation of Korean pediatric patients. The test is frequently requested along with the serum creatinine test since simultaneous determination of these 2 compounds appears to aid in the differential diagnosis of prerenal, renal and postrenal hyperuremia.Establishment of Pediatric Reference Intervals for Routine Laboratory Tests in Korean Population: A Retrospective Multicenter Analysis The determination of serum BUN currently is the most widely used screening test for the evaluation of kidney function. Increased blood urea nitrogen (BUN) may be due to prerenal causes (cardiac decompensation, water depletion due to decreased intake and excessive loss, increased protein catabolism, and high protein diet), renal causes (acute glomerulonephritis, chronic nephritis, polycystic kidney disease, nephrosclerosis, and tubular necrosis), and postrenal causes (eg, all types of obstruction of the urinary tract, such as stones, enlarged prostate gland, tumors). ![]() This is the most important catabolic pathway for eliminating excess nitrogen in the human body. The ammonia formed in this process is synthesized to urea in the liver. In protein catabolism, the proteins are broken down to amino acids and deaminated. Urea is the final degradation product of protein and amino acid metabolism.
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